CXCR6 Protein-VLP
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- Target See all CXCR6 Proteins
- CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))
- Protein Type
- VLP
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human CXCR6 / CD186 Full Length Protein (VLP)
- Sequence
- Ala 2 - Leu 342
- Characteristics
- Human CXCR6 Full Length Protein (VLP) is expressed from human 293 cells (HEK293). It contains AA Ala 2 - Leu 342 (Accession # O00574-1).
- Endotoxin Level
- 1.0 EU per μg
- Top Product
- Discover our top product CXCR6 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, Arginine, pH 7.4
- Storage
- -80 °C
- Storage Comment
- -70°C
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- Target
- CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))
- Alternative Name
- CXCR6 (CXCR6 Products)
- Synonyms
- BONZO Protein, CD186 Protein, STRL33 Protein, TYMSTR Protein, BB217514 Protein, C-X-C motif chemokine receptor 6 Protein, chemokine (C-X-C motif) receptor 6 L homeolog Protein, chemokine (C-X-C motif) receptor 6 Protein, CXCR6 Protein, cxcr6.L Protein, Cxcr6 Protein
- Background
- The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]
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