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CXCR3 Protein-VLP

CXCR3 Origin: Human Host: HEK-293 Cells VLP
Catalog No. ABIN7488804
  • Target See all CXCR3 Proteins
    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
    Protein Type
    VLP
    Origin
    • 9
    • 3
    • 2
    Human
    Source
    • 4
    • 4
    • 3
    • 2
    HEK-293 Cells
    Purpose
    Human CXCR3 Full Length Protein (VLP)
    Sequence
    Val 2 - Leu 368
    Characteristics
    Human CXCR3 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 368 (Accession # P49682-1).
    Endotoxin Level
    1.0 EU per μg
    Top Product
    Discover our top product CXCR3 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, Arginine, pH 7.4
    Storage
    -80 °C
    Storage Comment
    -70°C
  • Target
    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
    Alternative Name
    CXCR3 (CXCR3 Products)
    Synonyms
    CD182 Protein, CD183 Protein, CKR-L2 Protein, CMKAR3 Protein, GPR9 Protein, IP10-R Protein, Mig-R Protein, MigR Protein, Cd183 Protein, Cmkar3 Protein, CXCR3 Protein, cxcr3 Protein, Gpr9 Protein, CXC-R3 Protein, CXCR-3 Protein, zgc:92301 Protein, sb:eu378 Protein, C-X-C motif chemokine receptor 3 Protein, chemokine (C-X-C motif) receptor 3 Protein, chemokine (C-X-C motif) receptor 3, tandem duplicate 2 Protein, chemokine (C-X-C motif) receptor 3, tandem duplicate 1 Protein, CXCR3 Protein, Cxcr3 Protein, cxcr3 Protein, cxcr3.2 Protein, cxcr3.1 Protein
    Background
    Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
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