Claudin 9 Protein-VLP (CLDN9)

Catalog No. ABIN7488753

Product Details

Target: Claudin 9 (CLDN9)

Protein Type: VLP

Origin: Human

Source: HEK-293 Cells

Purpose: Human Claudin-9 / CLDN9 Full Length Protein (VLP)

Sequence: Met 1 -Val 217

Characteristics: Human Claudin-9 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Met 1 -Val 217 (Accession # O95484-1).

Endotoxin Level: 1.0 EU per μg

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, Arginine, pH 7.4

Storage: -80 °C

Storage Comment: -70°C

Target Details

Target: Claudin 9 (CLDN9)

Alternative Name: Claudin-9 (CLDN9 Products)

Synonyms: CLDN9 Protein, nmf329 Protein, claudin 9 Protein, CLDN9 Protein, Cldn9 Protein

Background: Claudin-9 belongs to the claudin family. Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junctions also play a critical role in maintaining cell polarity and signal transductions. Claudin-9 creates charge specific channels in the paracellular space, plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity, is required to preserve sensory cells in the hearing organ because claudin-9-defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph. Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs. Is one of the entry cofactors for hepatitis C virus, it enables HCV entry into target cells just as efficiently as CLDN1.

Pathways: Cell-Cell Junction Organization, Hepatitis C