Apelin Receptor Protein (APLNR)

Catalog No. ABIN7491545

Product Details

Target: Apelin Receptor (APLNR)

Protein Type: Synthetic Nanodisc

Origin: Human

Source: HEK-293 Cells

Purpose: Human APLNR full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Apelin Receptor (APLNR)

Alternative Name: APLNR (APLNR Products)

Synonyms: AGTRL1 Protein, APJ Protein, APJR Protein, HG11 Protein, Agtrl1 Protein, msr/apj Protein, Apj Protein, X-msr Protein, Xangio1 Protein, Xmsr Protein, agtrl1 Protein, angio1 Protein, apj Protein, apjr Protein, hg11 Protein, msr Protein, APLNR Protein, DKFZp469C1532 Protein, agtrl1-B Protein, agtrl1b Protein, Agtrl1a Protein, grn Protein, zgc:114063 Protein, APJa Protein, XAngio1 Protein, agtrl1-A Protein, agtrl1a Protein, aplnr-a Protein, aplnr-b Protein, x-MSR Protein, xAngio1 Protein, APLNR1 Protein, apelin receptor Protein, apelin receptor S homeolog Protein, apelin receptor b Protein, apelin receptor L homeolog Protein, APLNR Protein, Aplnr Protein, aplnr Protein, aplnr.S Protein, aplnrb Protein, aplnr.L Protein

Background: A member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

Molecular Weight: The human full length APLNR protein has a MW of 42.7 kDa

UniProt: P35414