Prostaglandin D2 Receptor 2 (PTGDR2) Protein
PTGDR2
Origin: Human
Host: HEK-293 Cells
Synthetic Nanodisc
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- Target See all Prostaglandin D2 Receptor 2 (PTGDR2) products
- Prostaglandin D2 Receptor 2 (PTGDR2)
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human PTGDR2 full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- Prostaglandin D2 Receptor 2 (PTGDR2)
- Alternative Name
- PTGDR2 (PTGDR2 Products)
- Synonyms
- CD294 Protein, CRTH2 Protein, DL1R Protein, DP2 Protein, GPR44 Protein, Crth2 Protein, Grp45 Protein, Ptgdr2 Protein, Gpr44 Protein, prostaglandin D2 receptor 2 Protein, PTGDR2 Protein, Ptgdr2 Protein
- Background
- The protein is a G-protein-coupled receptor that is preferentially expressed in CD4 effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.
- Molecular Weight
- The human full length PTGDR2 protein has a MW of 43.3 kDa
- UniProt
- Q9Y5Y4
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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