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- Target See all MC4R Proteins
- MC4R (Melanocortin 4 Receptor (MC4R))
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human MC4R full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Melanocortin 4 Receptor (MC4R) (AA 1-43) protein (Fc Tag)
MC4R Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Melanocortin 4 Receptor (MC4R) (AA 1-43) protein (GST tag)MC4R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Melanocortin 4 Receptor (MC4R) protein (Myc-DYKDDDDK Tag)MC4R Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- MC4R (Melanocortin 4 Receptor (MC4R))
- Alternative Name
- MC4R (MC4R Products)
- Synonyms
- zMC4 Protein, si:dkey-151m6.62 Protein, mc4r Protein, MC4R Protein, LOC100218148 Protein, Mc4-r Protein, melanocortin 4 receptor Protein, mc4r Protein, MC4R Protein, Mc4r Protein
- Background
- The protein is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
- Molecular Weight
- The human full length MC4R protein has a MW of 36.9 kDa
- UniProt
- P32245
- Pathways
- Hormone Transport, cAMP Metabolic Process, Feeding Behaviour
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