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GPR65 Protein

GPR65 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Catalog No. ABIN7491665
  • Target See all GPR65 Proteins
    GPR65 (G Protein-Coupled Receptor 65 (GPR65))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purpose
    Human GPR65 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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    Discover our top product GPR65 Protein
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    GPR65 (G Protein-Coupled Receptor 65 (GPR65))
    Alternative Name
    GPR65 (GPR65 Products)
    Synonyms
    tdag8 Protein, htdag8 Protein, TDAG8 Protein, hTDAG8 Protein, Dig1 Protein, Gpcr25 Protein, Tdag8 Protein, G protein-coupled receptor 65 Protein, G-protein coupled receptor 65 Protein, GPR65 Protein, gpr65 Protein, Gpr65 Protein
    Background
    Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).[UniProtKB/Swiss-Prot Function]
    Molecular Weight
    The human full length GPR65 protein has a MW of 39.3 kDa
    UniProt
    Q8IYL9
    Pathways
    cAMP Metabolic Process
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