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- Target See all TMCC3 products
- TMCC3 (Transmembrane and Coiled-Coil Domain Family 3 (TMCC3))
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human TMCC3 full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- TMCC3 (Transmembrane and Coiled-Coil Domain Family 3 (TMCC3))
- Alternative Name
- TMCC3 (TMCC3 Products)
- Synonyms
- wu:fb81d10 Protein, wu:fb83h01 Protein, wu:fk68a09 Protein, wu:fl22e07 Protein, si:dkey-183c16.4 Protein, DKFZp469H0211 Protein, AW488095 Protein, C630016B22Rik Protein, C88213 Protein, Tmcc1 Protein, RGD1307241 Protein, transmembrane and coiled-coil domain family 3 Protein, transmembrane and coiled coil domains 3 Protein, tmcc3 Protein, TMCC3 Protein, Tmcc3 Protein
- Background
- This protein belongs to the the transmembrane and coiled-coil domain (TMCC) family, which shares common structural motifs (two transmembrane domains and two coiled-coil domains). TMCC3 was isolated as a novel gene isolated from human brain, and later became known as a novel gene up-regulated in the developing brain, especially in the ventral tegmentum. There is no resolved structure or defined function.
- Molecular Weight
- The human full length TMCC3 protein has a MW of 53.8 kDa
- UniProt
- Q9ULS5
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