Angiotensin II Type-1 Receptor Protein

Catalog No. ABIN7491543

Product Details

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: HEK-293 Cells

Purpose: Human AGTR1 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Alternative Name: AGTR1 (AGTR1 Products)

Synonyms: AG2S Protein, AGTR1A Protein, AGTR1B Protein, AT1 Protein, AT1AR Protein, AT1B Protein, AT1BR Protein, AT1R Protein, AT2R1 Protein, AT2R1A Protein, AT2R1B Protein, HAT1R Protein, 1810074K20Rik Protein, AI551199 Protein, AT1a Protein, Agtr-1a Protein, Agtr1 Protein, Angtr-1a Protein, AT1A Protein, XAT-1 Protein, agtr1-A Protein, agtr1.2 Protein, AT1-R Protein, at1 Protein, AGTR1 Protein, Agtr-1b Protein, Angtr-1b Protein, agtr1 Protein, agtr1-a Protein, agtr1-b Protein, xAT Protein, angiotensin II receptor type 1 Protein, angiotensin II receptor, type 1a Protein, angiotensin II receptor type 1 S homeolog Protein, uncharacterized AGTR1 Protein, angiotensin II receptor, type 1b Protein, angiotensin II receptor type 1 L homeolog Protein, AGTR1 Protein, Agtr1a Protein, agtr1.S Protein, Agtr1 Protein, Agtr1b Protein, agtr1.L Protein

Background: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]

Molecular Weight: The human full length AGTR1 protein has a MW of 40.9 kDa

UniProt: P30556

Pathways: JAK-STAT Signaling, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour