CXCR1 Protein

Catalog No. ABIN7491619

Product Details

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: HEK-293 Cells

Purpose: Human CXCR1 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Alternative Name: CXCR1 (CXCR1 Products)

Synonyms: C-C Protein, C-C-CKR-1 Protein, CD128 Protein, CD181 Protein, CDw128a Protein, CKR-1 Protein, CMKAR1 Protein, IL8R1 Protein, IL8RA Protein, IL8RBA Protein, Il8ra Protein, CXCR-1 Protein, IL-8RA Protein, CXCR2 Protein, IL8RB Protein, cxcr1 Protein, cxcr2 Protein, C-X-C motif chemokine receptor 1 Protein, chemokine (C-X-C motif) receptor 1 Protein, C-X-C chemokine receptor type 1 Protein, C-X-C motif chemokine receptor 1 S homeolog Protein, CXCR1 Protein, Cxcr1 Protein, LOC100461947 Protein, cxcr1.S Protein

Background: The protein is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

Molecular Weight: The human full length CXCR1 protein has a MW of 39.8 kDa

UniProt: P25024

Pathways: cAMP Metabolic Process