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- Target See all GLUT12 (SLC2A12) Proteins
- GLUT12 (SLC2A12) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 12 (SLC2A12))
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human SLC2A12 full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- GLUT12 (SLC2A12) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 12 (SLC2A12))
- Alternative Name
- SLC2A12 (SLC2A12 Products)
- Synonyms
- zgc:66027 Protein, zgc:85776 Protein, SLC2A12 Protein, GLUT12 Protein, GLUT8 Protein, GLUT-12 Protein, Glut12 Protein, glut12 Protein, solute carrier family 2 (facilitated glucose transporter), member 12 Protein, solute carrier family 2 member 12 Protein, solute carrier family 2 (facilitated glucose transporter), member 12 L homeolog Protein, slc2a12 Protein, SLC2A12 Protein, Slc2a12 Protein, slc2a12.L Protein
- Background
- SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
- Molecular Weight
- The human full length SLC2A12 protein has a MW of 67 kDa
- UniProt
- Q8TD20
- Pathways
- Warburg Effect
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