ESYT1 Protein
ESYT1
Origin: Human
Host: HEK-293 Cells
Synthetic Nanodisc
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- Target See all ESYT1 products
- ESYT1 (Extended Synaptotagmin-Like Protein 1 (ESYT1))
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human ESYT1 full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Extended Synaptotagmin-Like Protein 1 (ESYT1) protein (Myc-DYKDDDDK Tag)
ESYT1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- ESYT1 (Extended Synaptotagmin-Like Protein 1 (ESYT1))
- Alternative Name
- ESYT1 (ESYT1 Products)
- Synonyms
- FAM62A Protein, fam62a Protein, si:ch211-239j9.4 Protein, DKFZp459I1628 Protein, MBC2 Protein, Fam62a Protein, Mbc2 Protein, vp115 Protein, extended synaptotagmin 1 Protein, extended synaptotagmin-like protein 1b Protein, extended synaptotagmin-like protein 1 Protein, ESYT1 Protein, esyt1b Protein, Esyt1 Protein
- Background
- Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.[UniProtKB/Swiss-Prot Function]
- Molecular Weight
- The human full length ESYT1 protein has a MW of 122.9 kDa
- UniProt
- Q9BSJ8
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