SLC4A7 Protein

Catalog No. ABIN7491737

Product Details

Target: SLC4A7 (Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7 (SLC4A7))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: HEK-293 Cells

Purpose: Human SLC4A7 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: SLC4A7 (Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7 (SLC4A7))

Alternative Name: SLC4A7 (SLC4A7 Products)

Synonyms: nbc2 Protein, nbc3 Protein, sbc2 Protein, nbcn1 Protein, slc4a6 Protein, MGC83246 Protein, SLC4A7 Protein, NBC2 Protein, NBC3 Protein, NBCN1 Protein, SBC2 Protein, SLC4A6 Protein, E430014N10Rik Protein, NBCn1 Protein, NBCn1-G Protein, solute carrier family 4 member 7 Protein, solute carrier family 4, sodium bicarbonate cotransporter, member 7 L homeolog Protein, solute carrier family 4, sodium bicarbonate cotransporter, member 7 Protein, SLC4A7 Protein, slc4a7.L Protein, slc4a7 Protein, Slc4a7 Protein

Background: This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

Molecular Weight: The human full length SLC4A7 protein has a MW of 136.5 kDa

UniProt: Q9Y6M7