Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

STEAP1 Protein

STEAP1 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Catalog No. ABIN7491743
  • Target See all STEAP1 Proteins
    STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purpose
    Human STEAP1 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))
    Alternative Name
    STEAP1 (STEAP1 Products)
    Synonyms
    PRSS24 Protein, STEAP Protein, STEAP1 Protein, 2410007B19Rik Protein, Prss24 Protein, Steap Protein, STEAP family member 1 Protein, six transmembrane epithelial antigen of the prostate 1 Protein, STEAP1 Protein, Steap1 Protein
    Background
    STEAP1 is a cell-surface biomolecule composed by sixtransmembrane domains connected by intra- and extracellular loops. It is commonly found overexpressed in several types of cancers, namely in PCa, and is preferentially located at the tight or gap junctions. However, in nontumoural tissues and vital organs, STEAP1 protein presents low or absent expression, unveiling considerable specificity for cancer environment. Taking into account STEAP1 predicted transmembrane topology and cellular localization, it has been hypothesized that STEAP1 may play an important role as a transporter protein and can be involved in intercellular communication.
    Molecular Weight
    The human full length STEAP1 protein has a MW of 39.9 kDa
    UniProt
    Q9UHE8
    Pathways
    Transition Metal Ion Homeostasis
You are here:
Support