KCNK9 Protein

Catalog No. ABIN7491685

Product Details

Target: KCNK9 (Potassium Channel, Subfamily K, Member 9 (KCNK9))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: HEK-293 Cells

Purpose: Human KCNK9 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: KCNK9 (Potassium Channel, Subfamily K, Member 9 (KCNK9))

Alternative Name: KCNK9 (KCNK9 Products)

Synonyms: Task3 Protein, K2p9.1 Protein, KT3.2 Protein, TASK-3 Protein, TASK3 Protein, KCNK9 Protein, LOC799704 Protein, Kcnk9 Protein, task3 Protein, k2p9.1 Protein, task-3 Protein, kt3.2 Protein, potassium channel, subfamily K, member 9 Protein, potassium two pore domain channel subfamily K member 9 Protein, potassium channel, two pore domain subfamily K, member 9 Protein, potassium channel, two pore domain subfamily K, member 9 L homeolog Protein, Kcnk9 Protein, KCNK9 Protein, kcnk9 Protein, kcnk9.L Protein

Background: This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH -dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Molecular Weight: The human full length KCNK9 protein has a MW of 42.3 kDa

UniProt: Q9NPC2