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- Target See all TSPAN33 Proteins
- TSPAN33 (Tetraspanin 33 (TSPAN33))
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- HEK-293 Cells
- Purpose
- Human TSPAN33 full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- TSPAN33 (Tetraspanin 33 (TSPAN33))
- Alternative Name
- TSPAN33 (TSPAN33 Products)
- Synonyms
- zgc:92266 Protein, PEN Protein, 1300010A20Rik Protein, AI035228 Protein, Pen Protein, RGD1560915 Protein, tetraspanin 33 Protein, tetraspanin 33a Protein, tetraspanin 33 L homeolog Protein, TSPAN33 Protein, tspan33a Protein, tspan33.L Protein, Tspan33 Protein
- Background
- Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
- Molecular Weight
- The human full length TSPAN33 protein has a MW of 31.5 kDa
- UniProt
- Q86UF1
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