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TRPA1 Protein

TRPA1 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Catalog No. ABIN7491751
  • Target See all TRPA1 Proteins
    TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 5
    • 3
    Human
    Source
    • 4
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purpose
    Human TRPA1 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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    Discover our top product TRPA1 Protein
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))
    Alternative Name
    TRPA1 (TRPA1 Products)
    Synonyms
    trpa1 Protein, ANKTM1 Protein, Anktm1 Protein, CG5751 Protein, CG5761 Protein, CT18073 Protein, DmTRPA1 Protein, Dmel\\CG5751 Protein, TRPA Protein, TRPA1 Protein, TrpA Protein, dANKTM1 Protein, dTRPA Protein, dTRPA1 Protein, dTrpA Protein, dTrpA1 Protein, dtrpA1 Protein, trpA1 Protein, GLEAN_02449 Protein, FEPS Protein, transient receptor potential cation channel, subfamily A, member 1a Protein, Transient receptor potential cation channel A1 Protein, transient receptor potential cation channel subfamily A member 1 Protein, transient receptor potential A1 Protein, tryptophan synthase subunit alpha 1 Protein, transient receptor potential cation channel, subfamily A, member 1 Protein, TRPA cation channel homolog Protein, trpa1a Protein, TrpA1 Protein, TRPA1 Protein, LOC658860 Protein, LOC694623 Protein, trpA1 Protein, trpa1 Protein, Trpa1 Protein, trpa-1 Protein
    Background
    The structure of the protein is highly related to both the protein ankyrin and transmembrane proteins. This protein is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
    Molecular Weight
    The human full length TRPA1 protein has a MW of 127.5 kDa
    UniProt
    O75762
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