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CD63 Protein (CD63)

CD63 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Catalog No. ABIN7491586
  • Target See all CD63 Proteins
    CD63
    Protein Type
    Synthetic Nanodisc
    Origin
    • 7
    • 2
    • 1
    Human
    Source
    • 4
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purpose
    Human CD63 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product CD63 Protein
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    CD63
    Alternative Name
    CD63 (CD63 Products)
    Synonyms
    C75951 Protein, ME491 Protein, Tspan30 Protein, LAMP-3 Protein, MLA1 Protein, OMA81H Protein, TSPAN30 Protein, TSP29FA Protein, CD63 antigen Protein, CD63 molecule Protein, Cd63 molecule Protein, Cd63 Protein, CD63 Protein
    Background
    The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
    Molecular Weight
    The human full length CD63 protein has a MW of 25.6 kDa
    UniProt
    P08962
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