GRPR Protein (AA 1-38) (Fc Tag)
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- Target See all GRPR Proteins
- GRPR (Gastrin-Releasing Peptide Receptor (GRPR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-38
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GRPR protein is labelled with Fc Tag.
- Purpose
- Recombinant Human GRPR Protein with C-terminal human Fc tag
- Specificity
- GRPR (Met1-Gly38) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product GRPR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- GRPR (Gastrin-Releasing Peptide Receptor (GRPR))
- Alternative Name
- GRPR (GRPR Products)
- Synonyms
- GRPR Protein, GRP-R Protein, gastrin releasing peptide receptor Protein, GRPR Protein, Grpr Protein
- Background
- Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
- Molecular Weight
- predicted molecular mass of 30.4 kDa after removal of the signal peptide. The apparent molecular mass of GRPR-hFc is 35-55 kDa due to glycosylation.
- UniProt
- P30550
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