LDLR Protein (AA 22-788) (His tag)
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- Target See all LDLR Proteins
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-788
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LDLR protein is labelled with His tag.
- Purpose
- Recombinant Human LDLR Protein with C-terminal 6xHis tag
- Specificity
- LDLR (Ala22-Arg788) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product LDLR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- Alternative Name
- LDLR (LDLR Products)
- Synonyms
- FH Protein, FHC Protein, LDLCQ2 Protein, Hlb301 Protein, LDLRA Protein, LDLA Protein, LDL receptor-2 Protein, fhc Protein, ldlcq2 Protein, ldlr Protein, ldlr2-a Protein, LDL receptor 1 Protein, ldlr-a Protein, ldlr-b Protein, low density lipoprotein receptor Protein, low density lipoprotein receptor a Protein, low density lipoprotein receptor S homeolog Protein, low density lipoprotein receptor L homeolog Protein, LDLR Protein, Ldlr Protein, ldlra Protein, ldlr.S Protein, ldlr.L Protein
- Background
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Molecular Weight
- predicted molecular mass of 85.6 kDa after removal of the signal peptide. The apparent molecular mass of LDLR-His is 100-130 kDa due to glycosylation.
- UniProt
- P01130
- Pathways
- Hepatitis C, Lipid Metabolism
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