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CNTF Protein

CNTF Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7455693
  • Target See all CNTF Proteins
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Protein Type
    Recombinant
    Origin
    • 13
    • 8
    • 3
    • 2
    • 2
    • 2
    Human
    Source
    • 21
    • 3
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed.
    Characteristics
    Extracellular Domain Protein
    Purification
    Affinity purification
    Purity
    Greater than 95 % as determined by reducing SDS-PAGE.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, pH 8.0.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Alternative Name
    CNTF (CNTF Products)
    Background
    Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83 % homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.
    Molecular Weight
    22.93 KDa
    UniProt
    P26441
    Pathways
    JAK-STAT Signaling
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