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CNTF Protein

CNTF Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7455693
  • Target See all CNTF Proteins
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Protein Type
    Recombinant
    Origin
    • 15
    • 8
    • 3
    • 2
    • 2
    • 2
    Human
    Source
    • 22
    • 3
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed.
    Characteristics
    Extracellular Domain Protein
    Purification
    Affinity purification
    Purity
    Greater than 95 % as determined by reducing SDS-PAGE.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, pH 8.0.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Alternative Name
    CNTF (CNTF Products)
    Synonyms
    GPA Protein, CNTF Protein, HCNTF Protein, AI429687 Protein, ciliary neurotrophic factor Protein, CNTF Protein, Cntf Protein
    Background
    Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83 % homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.
    Molecular Weight
    22.93 KDa
    UniProt
    P26441
    Pathways
    JAK-STAT Signaling
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