CCL23 Protein

Catalog No. ABIN7455691

Product Details

Target: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human C-C Motif Chemokine 23 is produced by our E.coli expression system and the target gene encoding Arg46-Asn120 is expressed.

Characteristics: Extracellular Domain Protein

Purification: Affinity purification

Purity: Greater than 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.2.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Alternative Name: CCL23 (CCL23 Products)

Synonyms: CK-BETA-8 Protein, CKb8 Protein, Ckb-8 Protein, Ckb-8-1 Protein, MIP-3 Protein, MIP3 Protein, MPIF-1 Protein, SCYA23 Protein, hmrp-2a Protein, C-C motif chemokine 23 Protein, C-C motif chemokine ligand 23 Protein, chemokine (C-C motif) ligand 23 Protein, LOC508666 Protein, CCL23 Protein

Background: Human Chemokine (C-C Motif) Ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1, CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 amino acid residue signal peptide that is cleaved to generate a 99 amino acid residue mature CCL23 (amino acids 22 -120). Additional N-terminal Processing of the 99 amino acid residue variant can generate a 75 amino acid residue peptide (amino acid 46-120) that is significantly more active than the 99 amino acid residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes, dendritic cells, and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells, but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.

Molecular Weight: 8.7 KDa

UniProt: P55773