IL28B Protein

Catalog No. ABIN7455683

Product Details

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purpose: Recombinant Human Interleukin-28B is produced by our Mammalian expression system and the target gene encoding Val22-Val196 is expressed.

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: Greater than 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Alternative Name: IL-28B (IL28B Products)

Synonyms: Il28b Protein, IFL-1 Protein, IL-28B Protein, INF-alpha Protein, INF-lambda Protein, Il28 Protein, IL28B Protein, IL28C Protein, interferon, lambda 3 Protein, interferon lambda 3 Protein, Ifnl3 Protein, IFNL3 Protein

Background: Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Molecular Weight: 19.6 KDa

UniProt: Q8IZI9