CCL26 Protein

Catalog No. ABIN7455613

Product Details

Target: CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human C-C Motif Chemokine 26 is produced by our E.coli expression system and the target gene encoding Ser27-Leu94 is expressed.

Characteristics: Extracellular Domain Protein

Purification: Affinity purification

Purity: Greater than 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Storage: 4 °C,-20 °C

Storage Comment: Lyophilized protein should be stored at -20°C or lower, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C or lower for 3 months. The product is shipped at ambient temperature. Upon receipt, store it immediately at the proper temperature.

Expiry Date: 12 months

Target Details

Target: CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))

Alternative Name: CCL26 (CCL26 Products)

Synonyms: CCL26 Protein, IMAC Protein, MIP-4a Protein, MIP-4alpha Protein, SCYA26 Protein, TSC-1 Protein, Ccl26l Protein, C-C motif chemokine ligand 26 Protein, chemokine (C-C motif) ligand 26 Protein, CCL26 Protein, Ccl26 Protein

Background: Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family, which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, Eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.

Molecular Weight: Predicted MW is 8.21 Kda. Protein runs at 13KDa under reducing conditions.

UniProt: Q9Y258

Pathways: Regulation of Actin Filament Polymerization