Neuropilin 1 Protein (NRP1) (AA 22-856) (His tag)

Catalog No. ABIN7491103

Product Details

Target: Neuropilin 1 (NRP1)

Protein Type: Recombinant

Protein Characteristics: AA 22-856

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Neuropilin 1 protein is labelled with His tag.

Purpose: Recombinant human NRP1 protein with C-terminal 6xHis tag

Specificity: NRP1 (Phe22-Pro856) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Neuropilin 1 (NRP1)

Alternative Name: CD304 (NRP1 Products)

Synonyms: NRP1 Protein, cd304 Protein, neuropilin Protein, np-1 Protein, npn-1 Protein, nrp Protein, nrp-1 Protein, vegf165r Protein, BDCA4 Protein, CD304 Protein, NP1 Protein, NRP Protein, VEGF165R Protein, C530029I03 Protein, NP-1 Protein, NPN-1 Protein, Npn1 Protein, Nrp Protein, neuropilin 1 Protein, neuropilin 1 L homeolog Protein, NRP1 Protein, nrp1 Protein, Nrp1 Protein, nrp1.L Protein

Background: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors, they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

Molecular Weight: predicted molecular mass of 94.6 kDa after removal of the signal peptide. The apparent molecular mass of CD304-His is 100-130 kDa due to glycosylation.

UniProt: O14786

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals