IL17RA Protein (AA 32-322) (His tag)

Catalog No. ABIN7491057

Product Details

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Protein Type: Recombinant

Protein Characteristics: AA 32-322

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This IL17RA protein is labelled with His tag.

Purpose: Recombinant mouse IL17RA protein with C-terminal 6xHis tag

Specificity: Mouse IL17RA (Ser32-Trp322) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: IL17RA (Interleukin 17 Receptor A (IL17RA))

Alternative Name: IL17RA (IL17RA Products)

Synonyms: IL17R Protein, CANDF5 Protein, CD217 Protein, CDw217 Protein, IL-17RA Protein, hIL-17R Protein, Il17r Protein, AW538159 Protein, Cdw217 Protein, VDw217 Protein, interleukin 17 receptor A Protein, IL17RA Protein, Il17ra Protein

Background: Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity).[UniProtKB/Swiss-Prot Function]

Molecular Weight: predicted molecular mass of 34.1kDa after removal of the signal peptide. The apparent molecular mass of mIL17RA-His is 55-70 kDa due to glycosylation.

UniProt: Q60943

Pathways: SARS-CoV-2 Protein Interactome