NPC1L1 Protein (AA 22-284) (His tag)
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- Target See all NPC1L1 Proteins
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-284
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NPC1L1 protein is labelled with His tag.
- Purpose
- Recombinant human NPC1L1 protein with C-terminal 6xHis tag
- Specificity
- NPC1L1 (Glu22-Ser284) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product NPC1L1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- Alternative Name
- NPC1L1 (NPC1L1 Products)
- Synonyms
- NPC1L1 Protein, 9130221N23Rik Protein, Gm243 Protein, NPC11L1 Protein, NPC1 like intracellular cholesterol transporter 1 Protein, NPC1 like 1 Protein, NPC1-like 1 Protein, NPC1L1 Protein, npc1l1 Protein, Npc1l1 Protein
- Background
- The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- Molecular Weight
- predicted molecular mass of 28.8 kDa after removal of the signal peptide. The apparent molecular mass of NPC1L1-His is 35-55 kDa due to glycosylation.
- UniProt
- Q9UHC9
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