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HLA-A*24:02 (Monomer) protein (Survivin 2B)

Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Catalog No. ABIN7454357
  • Target
    HLA-A*24:02
    Protein Type
    Recombinant
    Protein Characteristics
    Monomer
    Origin
    Human
    Source
    • 9
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    Survivin 2B
    Purpose
    Human HLA-A*24:02 & B2M & Survivin 2B (AYACNTSTL) Monomer Protein
    Sequence
    Gly25-Thr305 (HLA-A*24:02), Ile21-Met119 (B2M) and AYACNTSTL peptide
    Specificity
    Uni-Prot: AAA59600.1 (HLA-A*24:02), P61769 (B2M), AYACNTSTL
    Characteristics
    Recombinant Human Survivin 2B(HLA-A*24:02) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*24:02), Ile21-Met119(B2M) and AYACNTSTL peptide.
    Purity
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    HLA-A*24:02
    Background
    Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus.
    Molecular Weight
    50.20 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Tris-Bis PAGE result.
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