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Tspan-8 Protein (His tag)

TSPAN8 Origin: Cynomolgus Host: HEK-293 Cells Recombinant 90,00 %
Catalog No. ABIN7317005
  • Target See all Tspan-8 (TSPAN8) Proteins
    Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))
    Protein Type
    Recombinant
    Origin
    • 6
    • 2
    • 1
    Cynomolgus
    Source
    • 5
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This Tspan-8 protein is labelled with His tag.
    Purpose
    Cynomolgus TSPAN8 Protein, His Tag
    Sequence
    Lys 110 - Ser 205
    Characteristics
    Cynomolgus TSPAN8, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 110 - Ser 205 (Accession # G7PI18-1).
    Purity
    90,00 %
    Endotoxin Level
    1.0 EU per μg
    Top Product
    Discover our top product TSPAN8 Protein
  • Comment

    This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 12.7 kDa. The protein migrates as 17-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -20 °C
    Storage Comment
    -20°C
  • Target
    Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))
    Alternative Name
    TSPAN8 (TSPAN8 Products)
    Synonyms
    tm4sf3 Protein, MGC64550 Protein, GB13255 Protein, TM4SF3 Protein, tetraspanin-8 Protein, tspan8 Protein, TSPAN8 Protein, CO-029 Protein, C76990 Protein, E330007O21Rik Protein, Tm4sf3 Protein, CO-29 Protein, TSPAN-8 Protein, tetraspanin 8 L homeolog Protein, tetraspanin-1 Protein, tetraspanin 8 Protein, tspan8.L Protein, LOC409511 Protein, TSPAN8 Protein, tspan8 Protein, Tspan8 Protein
    Background
    Synonyms:CO-029,tetraspanin 8,TM4SF3,TM4SF3tspan-8,Transmembrane 4 superfamily member 3tetraspanin-8,TSPAN8,Tspan-8,Tumor-associated antigen CO-029,Description:Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form 'tetraspanin webs'. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell-cell and cell-matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.
    Molecular Weight
    12.7 kDa
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