ITGAV/ITGB8 Protein (Biotin,His-Avi Tag)
-
- Target See all ITGAV/ITGB8 products
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- Protein Type
- Recombinant
-
Origin
- Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ITGAV/ITGB8 protein is labelled with Biotin,His-Avi Tag.
- Purpose
- Biotinylated Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag™&Tag Free
- Sequence
- Phe 31 - Val 988 & Gly 22 - Leu 681
- Characteristics
- Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 22 - Leu 681 (Accession # P43406-1 & Q0VBD0-1).
- Purity
- 95,00 %
- Endotoxin Level
- 1.0 EU per μg
-
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-993) protein (His tag)
ITGAV/ITGB8 Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-988) (Active) protein (His tag)ITGAV/ITGB8 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB8 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB8 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
-
- Comment
-
Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB8 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
-
- Target
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- Alternative Name
- Integrin alpha V beta 8 (ITGAV/ITGB8 Products)
- Background
- Synonyms:Integrin alpha V beta 8,ITGAV&ITGB8,Description:Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
- Molecular Weight
- 114.2 kDa | 77.5 kDa
-
