ITGAV/ITGB5 Protein (Biotin,His-Avi Tag)
-
- Target See all ITGAV/ITGB5 products
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- Protein Type
- Recombinant
-
Origin
- Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ITGAV/ITGB5 protein is labelled with Biotin,His-Avi Tag.
- Purpose
- Biotinylated Mouse Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His,Avitag™&Tag Free
- Sequence
- Phe 31 - Val 988 & Gly 24 - Asn 719
- Characteristics
- Biotinylated Mouse ITGAV&ITGB5 Heterodimer Protein, His,Avitag&Tag Free is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 24 - Asn 719 (Accession # P43406-1 & O70309-1).
- Purity
- 95,00 %
- Endotoxin Level
- 1.0 EU per μg
-
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His-Avi Tag,Biotin)
ITGAV/ITGB5 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB5 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB5 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
-
- Comment
-
Biotinylated Mouse ITGAV&ITGB5 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB5). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB5 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa (ITGB5) and 125-145 kDa (ITGAV)under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
-
- Target
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- Alternative Name
- Integrin alpha V beta 5 (ITGAV/ITGB5 Products)
- Background
- Synonyms:Integrin alpha V beta 5,ITGAV&ITGB5,Description:Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
- Molecular Weight
- 114.2 kDa | 81.8 kDa
-
