CHI3L1 Protein (AA 22-383) (His tag)
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- Target See all CHI3L1 Proteins
- CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-383
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CHI3L1 protein is labelled with His tag.
- Purpose
- Human YKL-40/CHI3L1 Protein
- Sequence
- Tyr22-Thr383
- Characteristics
- Recombinant Human YKL-40/CHI3L1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr22-Thr383.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))
- Alternative Name
- YKL-40 (CHI3L1 Products)
- Synonyms
- AW208766 Protein, Brp39 Protein, Gp39 Protein, ASRT7 Protein, CGP-39 Protein, GP-39 Protein, GP39 Protein, HC-gp39 Protein, HCGP-3P Protein, YKL-40 Protein, YKL40 Protein, YYL-40 Protein, hCGP-39 Protein, GP38K Protein, CLP-1 Protein, SPC-40 Protein, SPS-40 Protein, Chil1 Protein, BP40 Protein, MGP-40 Protein, chitinase-like 1 Protein, chitinase 3 like 1 Protein, chitinase 3-like 1 (cartilage glycoprotein-39) Protein, Chil1 Protein, CHI3L1 Protein, Chi3l1 Protein
- Background
- YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
- Molecular Weight
- 41.6 kDa. Due to glycosylation, the protein migrates to 42-50 kDa based on Tris-Bis PAGE result.
- UniProt
- P36222
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