FLT1 Protein (His-Avi Tag,Biotin)
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- Target See all FLT1 Proteins
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FLT1 protein is labelled with His-Avi Tag,Biotin.
- Sequence
- Ser27-Asn756
- Purity
- > 95% as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human VEGF165 at 1μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human VEGF R1, His Tag with the EC50 of 26.9ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product FLT1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
- Alternative Name
- VEGF R1 (FLT1 Products)
- Synonyms
- FLT Protein, FLT-1 Protein, VEGFR-1 Protein, VEGFR1 Protein, FLT1 Protein, flt1b Protein, sFlt1 Protein, AI323757 Protein, Flt-1 Protein, fms related tyrosine kinase 1 Protein, FMS-related tyrosine kinase 1 Protein, vascular endothelial growth factor receptor 1 Protein, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Protein, FMS-like tyrosine kinase 1 Protein, vascular endothelial growth factor receptor-1 Protein, FLT1 Protein, Flt1 Protein, CpipJ_CPIJ012087 Protein, flt1 Protein, FLT-1 Protein
- Background
- FLT, FLT1, Flt-1, FRT, VEGF R1, VEGFR1,VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
- Molecular Weight
- 85.1 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.
- Pathways
- RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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