Thyroperoxidase Protein (AA 19-846) (His tag)
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- Target See all Thyroperoxidase (TPO) Proteins
- Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-846
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Thyroperoxidase protein is labelled with His tag.
- Purpose
- Human Thyroid Peroxidase Protein
- Sequence
- Phe19-Arg846
- Characteristics
- Recombinant Human Thyroid Peroxidase Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe19-Arg846.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 10 % Glycerol ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))
- Alternative Name
- Thyroid Peroxidase (TPO Products)
- Synonyms
- MSA Protein, TDH2A Protein, TPX Protein, TPO Protein, msa Protein, tpx Protein, xtpo Protein, LOC100218312 Protein, thyroid peroxidase Protein, TPO Protein, Tpo Protein, tpo Protein, LOC100547103 Protein
- Background
- Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune thyroid disease, for example, the expression of thyroid peroxidase is lost in papillary thyroid carcinoma.
- Molecular Weight
- 90.6 kDa. Due to glycosylation, the protein migrates to 95-105 kDa based on Tris-Bis PAGE result.
- Pathways
- Thyroid Hormone Synthesis
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