PD-1 Protein (AA 25-167) (Fc Tag)
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- Target See all PD-1 (PDCD1) Proteins
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 25-167
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PD-1 protein is labelled with Fc Tag.
- Purpose
- Mouse PD-1/PDCD1 Protein
- Sequence
- Leu25-Gln167
- Characteristics
- Recombinant Mouse PD-1/PDCD1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu25-Gln167.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 0.15μM as determined in SPR assay (Biacore T200). See testing image for detail.
- Top Product
- Discover our top product PDCD1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Alternative Name
- PD-1 (PDCD1 Products)
- Synonyms
- CD279 Protein, PD-1 Protein, PD1 Protein, SLEB2 Protein, hPD-1 Protein, hPD-l Protein, Ly101 Protein, Pdc1 Protein, programmed cell death 1 Protein, PDCD1 Protein, Pdcd1 Protein
- Background
- Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
- Molecular Weight
- 42.9 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
- NCBI Accession
- NP_032824
- Pathways
- Cancer Immune Checkpoints
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