NOTCH3 Protein (His-Avi Tag)
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- Target See all NOTCH3 Proteins
- NOTCH3 (Notch 3 (NOTCH3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NOTCH3 protein is labelled with His-Avi Tag.
- Sequence
- Ala40-Glu467
- Purity
- > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH3 Protein
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Notch 3 (NOTCH3) (AA 1378-1640) protein (His tag)
NOTCH3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Notch 3 (NOTCH3) (AA 40-467) protein (Fc Tag)NOTCH3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Notch 3 (NOTCH3) (AA 47-156) protein (GST tag)NOTCH3 Origin: Human Host: Wheat germ Recombinant WB, AP, AA, ELISA
Notch 3 (NOTCH3) (AA 40-467) (Active) protein (Fc Tag)NOTCH3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- NOTCH3 (Notch 3 (NOTCH3))
- Alternative Name
- Notch 3 (NOTCH3 Products)
- Synonyms
- CADASIL Protein, CASIL Protein, IMF2 Protein, AW229011 Protein, N3 Protein, hpbk Protein, fa14b08 Protein, notch5 Protein, wu:fa14b08 Protein, notch 3 Protein, NOTCH3 Protein, Notch3 Protein, notch3 Protein
- Background
- CADASIL, Notch homolog 3, Notch-3, NOTCH3,Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
- Molecular Weight
- 47.7 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on Tris-Bis PAGE result.
- UniProt
- Q9UM47
- Pathways
- Notch Signaling
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