Macrophage Scavenger Receptor 1 Protein (MSR1) (AA 77-451) (His tag)
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- Target See all Macrophage Scavenger Receptor 1 (MSR1) Proteins
- Macrophage Scavenger Receptor 1 (MSR1)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 77-451
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Macrophage Scavenger Receptor 1 protein is labelled with His tag.
- Purpose
- Human MSR1 Protein
- Sequence
- Lys77-Leu451
- Characteristics
- Recombinant Human MSR1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Lys77-Leu451.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Macrophage Scavenger Receptor 1 (MSR1)
- Alternative Name
- MSR1 (MSR1 Products)
- Synonyms
- CD204 Protein, SCARA1 Protein, SR-A Protein, SRA Protein, phSR1 Protein, phSR2 Protein, MRS-A Protein, MSR Protein, MSR-A Protein, SR-AI Protein, SR-AII Protein, Scara1 Protein, Scvr Protein, MSR1 Protein, RGD1564316 Protein, macrophage scavenger receptor 1 Protein, scavenger receptor class A member 5 Protein, MSR1 Protein, Msr1 Protein, SCARA5 Protein
- Background
- The macrophage scavenger receptor 1 (Msr1, also called SRA) is a pattern recognition receptor primarily expressed on myeloid cells, which plays an important role in the maintenance of immune homeostasis. Msr1 promotes the pathogenesis of virus-induced FH by enhancing induction of neutrophil NETosis and subsequent complement activation. Targeting Msr1 may be employed as a new immunotherapeutic strategy for FH.
- Molecular Weight
- 42.39 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.
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