LAIR1 Protein (AA 22-141) (His tag)
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- Target See all LAIR1 Proteins
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-141
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LAIR1 protein is labelled with His tag.
- Purpose
- Mouse LAIR1/CD305 Protein
- Sequence
- Gln22-Tyr141
- Characteristics
- Recombinant Mouse LAIR1/CD305 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln22-Tyr141.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product LAIR1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- Alternative Name
- LAIR1 (LAIR1 Products)
- Synonyms
- 5133400O11Rik Protein, BB115266 Protein, D7Bwg0421e Protein, Lair-1 Protein, mLair-1 Protein, CD305 Protein, LAIR-1 Protein, leukocyte-associated Ig-like receptor 1 Protein, leukocyte associated immunoglobulin like receptor 1 Protein, leukocyte-associated immunoglobulin-like receptor 1 Protein, Lair1 Protein, LAIR1 Protein
- Background
- LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
- Molecular Weight
- 14.6 kDa. Due to glycosylation, the protein migrates to 30-42 kDa based on Tris-Bis PAGE result.
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