ERBB3 Protein (His-Avi Tag,Biotin)
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- Target See all ERBB3 Proteins
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ERBB3 protein is labelled with His-Avi Tag,Biotin.
- Sequence
- Ser20-Thr643
- Purity
- > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Biotinylated Human Her3 at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-Her3 Antibody, hFc Tag with the EC50 17.6ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product ERBB3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
- Alternative Name
- Her3 (ERBB3 Products)
- Synonyms
- ErbB-3 Protein, HER3 Protein, LCCS2 Protein, MDA-BF-1 Protein, c-erbB-3 Protein, c-erbB3 Protein, erbB3-S Protein, p180-ErbB3 Protein, p45-sErbB3 Protein, p85-sErbB3 Protein, ERBB3 Protein, C76256 Protein, Erbb-3 Protein, Erbb3r Protein, Her3 Protein, nuc-ErbB3 Protein, erb-b2 receptor tyrosine kinase 3 Protein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Protein, ERBB3 Protein, Erbb3 Protein
- Background
- ErbB3, ErbB-3, HER3, HER3c-erbB-3, LCCS2, MDA-BF-1, MGC88033, p180-ErbB3, p45-sErbB3, p85-sErbB3, ERBB3,Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG).ation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
- Molecular Weight
- 71.6 kDa. Due to glycosylation, the protein migrates to 90-100 kDa based on Tris-Bis PAGE result.
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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