FGFR4 Protein (AA 22-369) (Fc Tag)
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- Target See all FGFR4 Proteins
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-369
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FGFR4 protein is labelled with Fc Tag.
- Purpose
- Human FGFR4 Protein
- Sequence
- Leu22-Asp369
- Characteristics
- Recombinant Human FGFR4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu22-Asp369.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 13.05 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Alternative Name
- FGFR4 (FGFR4 Products)
- Synonyms
- FGFR4 Protein, XFGFR-4 Protein, XFGFR-4a Protein, cd334 Protein, fgfr-4 Protein, jtk2 Protein, tkf Protein, xfgfr4 Protein, CD334 Protein, JTK2 Protein, TKF Protein, Fgfr-4 Protein, etID309818.21 Protein, wu:fc13h10 Protein, zgc:111935 Protein, fgfr-4c Protein, fgfr4 Protein, fibroblast growth factor receptor 4 Protein, fibroblast growth factor receptor 4 S homeolog Protein, FGFR4 Protein, fgfr4 Protein, Fgfr4 Protein, fgfr4.S Protein
- Background
- Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
- Molecular Weight
- 65.3 kDa. Due to glycosylation, the protein migrates to 80-95 kDa based on Tris-Bis PAGE result.
- UniProt
- P22455
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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