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DKK3 Protein (AA 23-350) (His-Avi Tag)

Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Catalog No. ABIN7274470
  • Target See all DKK3 products
    DKK3
    Protein Type
    Recombinant
    Protein Characteristics
    AA 23-350
    Origin
    • 10
    • 4
    • 1
    • 1
    Human
    Source
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This DKK3 protein is labelled with His-Avi Tag.
    Purpose
    Human DKK3 Protein
    Sequence
    Pro23-Ile350
    Characteristics
    Recombinant Human DKK3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Pro23-Ile350.
    Purity
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    DKK3
    Abstract
    DKK3 Products
    Synonyms
    REIC Protein, RIG Protein, reic Protein, dkk-3 Protein, AW061014 Protein, C87148 Protein, Reic Protein, p29 Protein, dickkopf WNT signaling pathway inhibitor 3 Protein, dickkopf WNT signaling pathway inhibitor 3 S homeolog Protein, DKK3 Protein, dkk3 Protein, dkk3.S Protein, Dkk3 Protein
    Background
    Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists.DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
    Molecular Weight
    39.5 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
    UniProt
    Q9UBP4
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