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CAMK1 Protein

CAMK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317143
  • Target See all CAMK1 Proteins
    CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))
    Protein Type
    Recombinant
    Origin
    • 7
    • 2
    • 1
    Human
    Source
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human CAMK1/CaMKI-alpha Protein
    Sequence
    Leu 2-Leu 370
    Characteristics
    A DNA sequence encoding the human CAMK1 (NP_003647.1) (Leu 2-Leu 370) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.
    Purity
    > 85 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    Please contact us for more information.
    Top Product
    Discover our top product CAMK1 Protein
  • Comment

    42 kDa

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 50 mM Tirs, 150 mM NaCl, 10 % glycerol, pH 7.5
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))
    Alternative Name
    CAMK1 (CAMK1 Products)
    Synonyms
    CAMKI Protein, Camki Protein, Gaip Protein, CG1495 Protein, Calcium/calmodulin-dependent protein kinase Protein, CamKI Protein, Dmel\\CG1495 Protein, caMKI Protein, camKI Protein, dCKI Protein, AI505105 Protein, CaMKIalpha Protein, D6Ertd263e Protein, cam-kia Protein, camk1 Protein, camkI Protein, calcium/calmodulin dependent protein kinase I Protein, calcium/calmodulin-dependent protein kinase I Protein, Calcium/calmodulin-dependent protein kinase I Protein, calcium/calmodulin-dependent protein kinase I L homeolog Protein, CAMK1 Protein, Camk1 Protein, CaMKI Protein, camk1.L Protein
    Background

    Background: Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. In neurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse. Calcium/calmodulin-dependent protein kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK and CAMK1D, is a member of the protein kinase superfamily and CaMK subfamily. It contains one protein kinase domain. CAMK1D is broadly expressed. It is highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Engineered overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to increased cell proliferation, and molecular and phenotypic alterations indicative of epithelial-mesenchymal transition (EMT), including loss of cell-cell adhesions and increased cell migration and invasion. CAMK1D is a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors.

    Synonym: Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; CaM-KI; CaM Kinase I Alpha; CaMKI-Alpha; CAMK1

    Molecular Weight
    41.5 kDa
    NCBI Accession
    NP_003647
    Pathways
    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Smooth Muscle Cell Migration
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