BTN2A2 Protein (Biotin)
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- Target See all BTN2A2 Proteins
- BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This BTN2A2 protein is labelled with Biotin.
- Purpose
- Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated
- Sequence
- Gln33-Val237
- Characteristics
- Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product BTN2A2 Protein
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butyrophilin, Subfamily 2, Member A2 (BTN2A2) (AA 30-244) protein (His tag)
BTN2A2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
butyrophilin, Subfamily 2, Member A2 (BTN2A2) (AA 33-262), (Isoform 2), (partial) protein (His-SUMO Tag)BTN2A2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
butyrophilin, Subfamily 2, Member A2 (BTN2A2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)BTN2A2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Comment
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55-80 kDa
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))
- Alternative Name
- BTN2A2 (BTN2A2 Products)
- Synonyms
- BT2.2 Protein, BTF2 Protein, Btn2 Protein, D030063K05 Protein, btf2 Protein, bt2.2 Protein, MGC88971 Protein, BTN2A2 Protein, BTN2A1 Protein, butyrophilin subfamily 2 member A2 Protein, butyrophilin, subfamily 2, member A2 Protein, butyrophilin subfamily 2 member A2 L homeolog Protein, BTN2A2 Protein, Btn2a2 Protein, btn2a2 Protein, btn2a2.L Protein, LOC100065830 Protein, LOC100348076 Protein
- Background
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Background: Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naive B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.
Synonym: Butyrophilin subfamily 2 member A2, BTN2A2
- Molecular Weight
- 51.5 kDa
- UniProt
- Q8WVV5
- Pathways
- Activated T Cell Proliferation
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