CTLA4 Protein (His tag)
-
- Target See all CTLA4 Proteins
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
- Protein Type
- Recombinant
- Biological Activity
- Active
-
Origin
- Guinea Pig
-
Source
- Yeast (Pichia pastoris)
- Purification tag / Conjugate
- This CTLA4 protein is labelled with His tag.
- Purpose
- Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)
- Sequence
- Ala37-Asp161
- Characteristics
- Recombinant Cavia porcellus CD152 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1μg/ml(100 μl/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug/ml .
- Top Product
- Discover our top product CTLA4 Protein
-
-
- Comment
-
18-40 kDa
- Restrictions
- For Research Use only
-
- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- Target
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
- Alternative Name
- CTLA-4/CD152 (CTLA4 Products)
- Synonyms
- CTLA-4 Protein, CTLA4 Protein, CD152 Protein, Cd152 Protein, Ctla-4 Protein, Ly-56 Protein, CD Protein, CELIAC3 Protein, GRD4 Protein, GSE Protein, IDDM12 Protein, sCTLA4 Protein, cytotoxic T-lymphocyte associated protein 4 Protein, cytotoxic T-lymphocyte-associated protein 4 Protein, CTLA4 Protein, Ctla4 Protein
- Background
-
Background: Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Synonym: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4
- Molecular Weight
- 14.1 kDa
- UniProt
- H0VUB1
- Pathways
- Cancer Immune Checkpoints
-