CD27 Protein (His tag)

Catalog No. ABIN7321004

Product Details

Target: CD27 (CD27 Molecule (CD27))

Protein Type: Recombinant

Origin: Rhesus Monkey

Source: Human Cells

Purification tag / Conjugate: This CD27 protein is labelled with His tag.

Purpose: Recombinant Rhesus macaque CD27/TNFRSF7 Protein (His Tag)

Sequence: Thr21-Ile192

Characteristics: Recombinant Rhesus macaque CD27 is produced by our Mammalian expression system and the target gene encoding Thr21-Ile192 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

40 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD27 (CD27 Molecule (CD27))

Alternative Name: CD27/TNFRSF7 (CD27 Products)

Synonyms: TNFRSF7 Protein, S152 Protein, Tnfrsf7 Protein, Tp55 Protein, S152. LPFS2 Protein, T14 Protein, CD27 molecule Protein, CD27 antigen Protein, CD27 Protein, Cd27 Protein

Background:

Background: CD27 antigen, also known as CD27L receptor, T-cell activation antigen CD27, T14, S152, Tp55, TNFRSF7 and Tumor necrosis factor receptor for superfamily member 7,belongs to the TNF-receptor superfamily. CD27 is a single-pass type I membrane protein and exists as a homodimer form, containing three TNFR-Cys repeats. CD27 transduces signals that lead to the activation of NF-KappaB and MAPK8/JNK. CD27 is involved in regulating B-cell activation and immunoglobulin synthesis, binding to the ligand CD70. TRAF2 and TRAF5 have been shown to mediate the signaling process of CD27. CD27-binding protein (SIVA), which is a proapoptotic protein, can bind to CD27 and is thought to play a key role in the apoptosis. CD27 is required for generation and long-term maintenance of T cell immunity.

Synonym: CD27 Antigen, CD27L Receptor, T-Cell Activation Antigen CD27, T14, Tumor Necrosis Factor Receptor Superfamily Member 7, CD27, CD27, TNFRSF7

Molecular Weight: 20.1 kDa

UniProt: F7BYS2

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints