ACE2 Protein (His tag)
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- Target See all ACE2 Proteins
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Rhesus Monkey
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Source
- Human Cells
- Purification tag / Conjugate
- This ACE2 protein is labelled with His tag.
- Purpose
- Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-10His)
- Sequence
- Gln18-Val739
- Characteristics
- Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Val739 is expressed with a 10His tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Rhesus Macaque ACE-2-His(Cat#PKSQ050119)at 5μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc(Cat#PKSR030476). The ED50 of Recombinant 2019-nCoV S Protein RBD-SD1-mFc(Cat#PKSR030476) is 16.8 ng/ml .
- Top Product
- Discover our top product ACE2 Protein
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- Comment
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90-120 kDa
- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 150 mM NaCl, 1 mM ZnCl2, pH 7.5.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
- Alternative Name
- ACE-2 (ACE2 Products)
- Synonyms
- ACE1 Protein, CD143 Protein, DCP Protein, DCP1 Protein, ICH Protein, MVCD3 Protein, ACEH Protein, 2010305L05Rik Protein, zgc:92514 Protein, angiotensin I converting enzyme Protein, angiotensin I converting enzyme 2 Protein, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Protein, ACE Protein, ACE2 Protein, Ace2 Protein, ace2 Protein
- Background
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Background: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don't inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Synonym: Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2
- Molecular Weight
- 85.1 kDa
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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