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TWF1 Protein

TWF1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 94 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317476
  • Target See all TWF1 Proteins
    TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))
    Protein Type
    Recombinant
    Origin
    • 6
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 3
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human TWF1/Twinfilin-1 Protein
    Sequence
    Met 1-Asp 252
    Characteristics
    A DNA sequence encoding the human TWF1 isoform 4 (Q12792-4) (Met 1-Asp 252) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
    Purity
    > 94 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product TWF1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4, 10 % glycerol
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))
    Alternative Name
    TWF1/Twinfilin-1 (TWF1 Products)
    Synonyms
    A6 Protein, PTK9 Protein, Ptk9 Protein, twinfilin Protein, ptk9 Protein, twf1 Protein, wu:fd02b03 Protein, zgc:65922 Protein, DKFZp469O1925 Protein, CG3771 Protein, Dmel\\CG3771 Protein, EG:9D2.3 Protein, zgc:92472 Protein, twinfilin actin binding protein 1 Protein, twinfilin actin-binding protein 1a Protein, twinfilin actin binding protein 1 S homeolog Protein, twinfilin-1 Protein, hypothetical protein Protein, Twinfilin-1 Protein, twinfilin actin-binding protein 1 Protein, CG3771 gene product from transcript CG3771-RC Protein, twinfilin actin-binding protein 1b Protein, TWF1 Protein, Twf1 Protein, twf1a Protein, twf1.S Protein, PTRG_09288 Protein, PGTG_01788 Protein, Tsp_02530 Protein, twf1 Protein, a6 Protein, twf1b Protein
    Background

    Background: Twinfilin-1; also known as Protein A6; Protein tyrosine kinase 9; TWF1 and PTK9; is a cytoplasm protein which belongs to the actin-binding proteins ADF family and Twinfilin subfamily. Twinfilin-1 (TWF1 / PTK9 ) is a highly conserved actin monomer-binding protein that regulates cytoskeletal dynamics in organisms from yeast to mammals. In addition to the mammalian twinfilin-1; a second protein with approximately 65% sequence identity to twinfilin-1 exists in mouse and humans. TWF1 / PTK9 is expressed at high levels in the colon; testis; ovary; prostate and lung. It is expressed at lower levels in the brain; bladder and heart. It is not detected in liver. TWF1 / PTK9 is an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization; likely by sequestering G-actin. By capping the barbed ends of filaments; it also regulates motility. TWF1 / PTK9 seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.

    Synonym: A6;MGC23788;MGC41876;PTK9

    Molecular Weight
    29 kDa
    Pathways
    Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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