HVEM Protein (Fc Tag)
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- Target See all HVEM (TNFRSF14) Proteins
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This HVEM protein is labelled with Fc Tag.
- Purpose
- Recombinant Mouse HVEM/TNFRSF14 Protein (Fc Tag)(Active)
- Sequence
- Gln39-Val207
- Characteristics
- Recombinant Mouse Herpesvirus Entry Mediator is produced by our Mammalian expression system and the target gene encoding Gln39-Val207 is expressed with a Fc tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Mouse HVEM-Fc at 6μg/ml(100 μl/well) can bind Human BTLA-His(Cat: PKSH033758). The ED50 of Mouse HVEM-Fc is 1.17ug/ml .
- Top Product
- Discover our top product TNFRSF14 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- Alternative Name
- HVEM/TNFRSF14 (TNFRSF14 Products)
- Synonyms
- ATAR Protein, CD270 Protein, HVEA Protein, HVEM Protein, LIGHTR Protein, TR2 Protein, Atar Protein, HveA Protein, Hvem Protein, Tnfrs14 Protein, TNF receptor superfamily member 14 Protein, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Protein, Tnfrsf14 Protein, TNFRSF14 Protein
- Target Type
- Viral Protein
- Background
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Background: Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.
Synonym: Tnfrsf14, Herpesvirus entry mediator,HVEM, TR2,TNF receptor-like molecule,ATAR,another TRAF-associated receptor,Tumor necrosis factor receptor superfamily member 14,Atar,HveA
- Molecular Weight
- 45.6 kDa
- NCBI Accession
- NP_849262
- Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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