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TPBG Protein (mFc Tag)

TPBG Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7319827
  • Target See all TPBG Proteins
    TPBG (Trophoblast Glycoprotein (TPBG))
    Protein Type
    Recombinant
    Origin
    • 13
    • 3
    • 3
    • 2
    • 1
    Human
    Source
    • 14
    • 2
    • 2
    • 2
    • 1
    Human Cells
    Purification tag / Conjugate
    This TPBG protein is labelled with mFc Tag.
    Purpose
    Recombinant Human TPBG/5T4 (C-mFc)
    Sequence
    Ser32-Ser355
    Characteristics
    Recombinant Human Trophoblast glycoprotein is produced by our Mammalian expression system and the target gene encoding Ser32-Ser355 is expressed with a mFc tag at the C-terminus.
    Purity
    >95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
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    Discover our top product TPBG Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    TPBG (Trophoblast Glycoprotein (TPBG))
    Alternative Name
    TPBG/5T4 (TPBG Products)
    Synonyms
    5T4 Protein, 5T4AG Protein, M6P1 Protein, AW495680 Protein, TPBG Protein, tpbg Protein, trophoblast glycoprotein Protein, trophoblast glycoprotein b Protein, TPBG Protein, Tpbg Protein, tpbgb Protein, tpbg Protein
    Background

    Background: Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

    Synonym: 5T4 , 5T4AG, M6P1, WAIF1

    Molecular Weight
    61.7 kDa
    UniProt
    Q13641
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