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TLK2 Protein

TLK2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317071
  • Target See all TLK2 Proteins
    TLK2 (Tousled-Like Kinase 2 (TLK2))
    Protein Type
    Recombinant
    Origin
    • 5
    • 1
    Human
    Source
    • 2
    • 1
    • 1
    • 1
    • 1
    Baculovirus infected Insect Cells
    Purpose
    Recombinant Human TLK2/PKU-ALPHA Protein
    Sequence
    Leu 397-Asn772
    Characteristics
    A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
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    Discover our top product TLK2 Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    TLK2 (Tousled-Like Kinase 2 (TLK2))
    Alternative Name
    TLK2/PKU-ALPHA (TLK2 Products)
    Synonyms
    tlk2 Protein, MGC149057 Protein, HsHPK Protein, PKU-ALPHA Protein, wu:fi16h09 Protein, wu:fi30g12 Protein, zgc:136697 Protein, 4933403M19Rik Protein, PKUalpha Protein, Tlk Protein, tousled like kinase 2 Protein, tousled-like kinase 2 Protein, tousled-like kinase 2 (Arabidopsis) Protein, tlk2 Protein, TLK2 Protein, Tlk2 Protein
    Background

    Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

    Synonym: HsHPK;PKU-ALPHA

    Molecular Weight
    43.6 kDa
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